The synthesis and characterization of novel platinum coordination complexes

Abstract

Platinum-based compounds represent one of the main forms of anticancer therapies. There are currently only three platinum compounds, cisplatin, carboplatin, and oxaliplatin, that have achieved widespread use as anticancer agents, and each presents issues with toxicity and resistance. As such, this study focuses on the generation of platinum-based coordination complexes which can undergo future biological testing. Three imines were generated from thereaction of 6-methyl-2-pyridinecarboxaldehyde with bulky cycloalkyl functionalized amines. This route of synthesis led to the production of the desired iminopyridine ligands in moderate yields. The imines were subsequently reacted with a half-equivalent of [PtCl2(h2- cis-cyclooctene)]2 in an attempt to produce platinum coordinated complexes. The bulky nature of the imines led to complications during ligand substitution, resulting in incomplete conversion to compounds 2a, 2b, and 2c. As such, reactions were attempted under a variety of conditions. All imines and fully synthesized platinum complexes were characterized using 1H NMR, 13C{1H} NMR, and FT-IR spectroscopy.