Synthesis and characterization of novel iminopyridinium platinum(II) coordination complexes as potential chemotherapeutic drugs

Abstract

This study focuses on the synthesis and characterization of five novel iminopyridinium ligands using an appropriate alkyl amine and 6-methyl-2-pyridinecarboxaldehyde. Synthesis of four platinum (II) complexes were achieved by chelating the appropriate ligand to [PtCl2(η2-coe)]2 (coe = cis-cyclooctene). The ligands were characterized using 1H, 13C{1H} nuclear magnetic resonance (NMR) and Fourier-Transformed Infrared spectroscopy (FT-IR). The complexes were characterized using 1H, 13C{1H} NMR and FT-IR spectroscopy and melting point analysis. An X-ray diffraction study was performed on dichloro-[(6-methylpyridin-2-yl)methylene)hexan-1-amine] platinum (II). Elemental analysis was also conducted on C1 and C2, however the data was inconclusive. Prospective work includes acquiring a more conclusive elemental analysis on all complexes and conducting bioactivity and cytotoxicity test on the synthesized complexes.