Iminophosphine platinum(II) complexes containing long chain aniline derivatives: Synthesis, characterization, and anticancer properties

Abstract

A series of iminophosphine ligands (1a-g) have been prepared from the condensation reaction of 2-(diphenylphosphino)benzaldehyde with aniline and aniline derivatives containing linear hydrocarbon chains of varying lengths in the para position. The corresponding platinum(II) complexes (2a-g) were synthesized by reaction of [PtCl2(η2-coe)]2 (coe = cis-cyclooctene) and two equivalents of 1a-g. Full characterization of all new ligands and platinum complexes was performed including multi-nuclear NMR spectroscopy as well as an X-ray diffraction study for compound 2d (derived from 4-hexylaniline). The cytotoxic properties of the platinum complexes against two glioma cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric method were examined.